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Magnetic Vascular Implants Promote Rapid Endothelialization

Newman, B; Dragomir-Daescu, D; Harbuzariu, A; McIntosh, M; Harburn, J.J; Parakka, A; Kalra, M; Holmes, D.J; Simari, R.D; Sandhu, G.S

Authors

B Newman

D Dragomir-Daescu

A Harbuzariu

M McIntosh

J.J Harburn

A Parakka

M Kalra

D.J Holmes

R.D Simari

G.S Sandhu



Abstract

Atherosclerosis is the most prevalent and costly public health threat in the world (WHO, 2006). Treatment often involves surgical placement of a vascular graft or stent, but these interventions are susceptible to thrombosis, inflammation, and neointimal hyperplasia in vivo. We designed and tested novel, rapidly-endothelializing, magnetic vascular grafts and stents. First, endothelial outgrowth cells endocytosed superparamagnetic microspheres in culture. The cells were then seeded onto magnetic stents and grafts for in vivo experimentation. Fourteen stents were implanted into pigs, showing superior resistance to inflammation, thrombosis, and neointimal hyperplasia relative to bare metal stents. Similarly, endothelial cell coated cobalt chromium – poly(ether urethane) composite grafts were implanted into pig arteries, exhibiting improved patency at one month follow-up. These studies facilitated materials selection and design of cardiovascular implants with superior efficacy and reduced development time.

Citation

Newman, B., Dragomir-Daescu, D., Harbuzariu, A., McIntosh, M., Harburn, J., Parakka, A., …Sandhu, G. (2010). Magnetic Vascular Implants Promote Rapid Endothelialization.

Conference Name Next Generation Biomaterials and Surface Properties of Biomaterials Symposia; Materials Science and Technology (MS&T'10)
Conference Location Houston, Texas
Start Date Oct 17, 2010
End Date Oct 20, 2010
Publication Date Oct 1, 2010
Deposit Date Oct 19, 2012
Publisher URL http://www.programmaster.org/PM/PM.nsf/ApprovedAbstracts/8CA701FF2899E3ED852576F5007A6CEB?OpenDocument
Additional Information 17-21 October 2010

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