Newman, B. and Dragomir-Daescu, D. and Harbuzariu, A. and McIntosh, M. and Harburn, J.J. and Parakka, A. and Kalra, M. and Holmes, D. and Simari, R. and Sandhu, G. (2010) 'Magnetic vascular implants promote rapid endothelialization.', Next Generation Biomaterials and Surface Properties of Biomaterials Symposia; Materials Science and Technology (MS&T'10) Houston, Texas, 17-20 October 2010.
Atherosclerosis is the most prevalent and costly public health threat in the world (WHO, 2006). Treatment often involves surgical placement of a vascular graft or stent, but these interventions are susceptible to thrombosis, inflammation, and neointimal hyperplasia in vivo. We designed and tested novel, rapidly-endothelializing, magnetic vascular grafts and stents. First, endothelial outgrowth cells endocytosed superparamagnetic microspheres in culture. The cells were then seeded onto magnetic stents and grafts for in vivo experimentation. Fourteen stents were implanted into pigs, showing superior resistance to inflammation, thrombosis, and neointimal hyperplasia relative to bare metal stents. Similarly, endothelial cell coated cobalt chromium – poly(ether urethane) composite grafts were implanted into pig arteries, exhibiting improved patency at one month follow-up. These studies facilitated materials selection and design of cardiovascular implants with superior efficacy and reduced development time.
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|Record Created:||24 Oct 2012 15:20|
|Last Modified:||02 Nov 2012 14:23|
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