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Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana

Roeder, Adrienne H.K.; Chickarmane, Vijay; Cunha, Alexandre; Obara, Boguslaw; Manjunath, B.S.; Meyerowitz, Elliot M.

Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana Thumbnail


Authors

Adrienne H.K. Roeder

Vijay Chickarmane

Alexandre Cunha

Boguslaw Obara

B.S. Manjunath

Elliot M. Meyerowitz



Abstract

How growth and proliferation are precisely controlled in organs during development and how the regulation of cell division contributes to the formation of complex cell type patterns are important questions in developmental biology. Such a pattern of diverse cell sizes is characteristic of the sepals, the outermost floral organs, of the plant Arabidopsis thaliana. To determine how the cell size pattern is formed in the sepal epidermis, we iterate between generating predictions from a computational model and testing these predictions through time-lapse imaging. We show that the cell size diversity is due to the variability in decisions of individual cells about when to divide and when to stop dividing and enter the specialized endoreduplication cell cycle. We further show that altering the activity of cell cycle inhibitors biases the timing and changes the cell size pattern as our model predicts. Models and observations together demonstrate that variability in the time of cell division is a major determinant in the formation of a characteristic pattern.

Citation

Roeder, A. H., Chickarmane, V., Cunha, A., Obara, B., Manjunath, B., & Meyerowitz, E. M. (2010). Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana. PLoS Biology, 8(5), Article e1000367. https://doi.org/10.1371/journal.pbio.1000367

Journal Article Type Article
Acceptance Date Apr 1, 2010
Online Publication Date May 11, 2010
Publication Date May 11, 2010
Deposit Date Jul 31, 2012
Publicly Available Date Mar 28, 2024
Journal PLoS Biology
Print ISSN 1544-9173
Electronic ISSN 1545-7885
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 8
Issue 5
Article Number e1000367
DOI https://doi.org/10.1371/journal.pbio.1000367

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright: © 2010 Roeder et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.





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