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Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9†‡

Ayub, M.; Irfan, M.; Maclean, A.; Naeem, F.; Blackwood, D.

Authors

M. Ayub

M. Irfan

A. Maclean

F. Naeem

D. Blackwood



Abstract

A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression.

Citation

Ayub, M., Irfan, M., Maclean, A., Naeem, F., & Blackwood, D. (2013). Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9†‡. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 157-162. https://doi.org/10.1002/ajmg.b.32126

Journal Article Type Article
Publication Date Mar 1, 2013
Deposit Date Jan 7, 2013
Journal American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Print ISSN 1552-4841
Electronic ISSN 1552-485X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 162
Issue 2
Pages 157-162
DOI https://doi.org/10.1002/ajmg.b.32126
Keywords Major depressive disorder, Homozygosity mapping, Pakistan, Genetic linkage.

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