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Group theory of icosahedral virus capsid vibrations: a top-down approach

Peeters, K.; Taormina, A.

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Authors



Abstract

We explore the use of a top-down approach to analyse the dynamics of icosahedral virus capsids and complement the information obtained from bottom-up studies of viral vibrations available in the literature. A normal mode analysis based on protein association energies is used to study the frequency spectrum, in which we reveal a universal plateau of low-frequency modes shared by a large class of Caspar–Klug capsids. These modes break icosahedral symmetry and are potentially relevant to the genome release mechanism. We comment on the role of viral tiling theory in such dynamical considerations.

Citation

Peeters, K., & Taormina, A. (2009). Group theory of icosahedral virus capsid vibrations: a top-down approach. Journal of Theoretical Biology, 256(4), 607-624. https://doi.org/10.1016/j.jtbi.2008.10.019

Journal Article Type Article
Publication Date Feb 1, 2009
Deposit Date Feb 9, 2011
Publicly Available Date Mar 28, 2024
Journal Journal of Theoretical Biology
Print ISSN 0022-5193
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 256
Issue 4
Pages 607-624
DOI https://doi.org/10.1016/j.jtbi.2008.10.019
Keywords Biomolecular assembly, Viruses, Normal modes of vibration.

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Copyright Statement
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of theoretical biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of theoretical biology, 256 (4), 2009, 10.1016/j.jtbi.2008.10.019





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