AC O'Farrell
Non-invasive molecular imaging for preclinical cancer therapeutic development
O'Farrell, AC; Shnyder, SD; Marston, G; Colletta, L; Gill, JH
Authors
SD Shnyder
G Marston
L Colletta
JH Gill
Abstract
Molecular and non-invasive imaging are rapidly emerging fields in preclinical cancer drug discovery. This is driven by the need to develop more efficacious and safer treatments, the advent of molecular targeted therapeutics, and the requirements to reduce and refine current preclinical in vivo models. Such bioimaging strategies include magnetic resonance imaging (MRI), positron emission tomography (PET), single positron emission computed tomography (SPECT), ultrasound, and optical approaches such as bioluminescence and fluorescence imaging. These molecular imaging modalities have several advantages over traditional screening methods, not least the ability to quantitatively monitor pharmacodynamic changes at the cellular and molecular level in living animals non-invasively in real-time. This review aims to provide an overview of non-invasive molecular imaging techniques, highlighting the strengths, limitations and versatility of these approaches in preclinical cancer drug discovery and development.
Citation
O'Farrell, A., Shnyder, S., Marston, G., Colletta, L., & Gill, J. (2013). Non-invasive molecular imaging for preclinical cancer therapeutic development. British Journal of Pharmacology, 169(4), 719-735. https://doi.org/10.1111/bph.12155
Journal Article Type | Article |
---|---|
Publication Date | Jun 1, 2013 |
Deposit Date | Mar 4, 2013 |
Publicly Available Date | May 23, 2013 |
Journal | British Journal of Pharmacology |
Print ISSN | 0007-1188 |
Electronic ISSN | 1476-5381 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 169 |
Issue | 4 |
Pages | 719-735 |
DOI | https://doi.org/10.1111/bph.12155 |
Keywords | Non-invasive imaging, Cancer Pharmacology, Bioluminescence, Ultrasound, Positron Emission Tomography (PET), Magnetic resonance imaging (MRI). |
Files
Accepted Journal Article
(329 Kb)
PDF
Copyright Statement
This is the peer reviewed version of the following article: O'Farrell, A., Shnyder, S., Marston, G., Coletta, P. and Gill, J. (2013), Non-invasive molecular imaging for preclinical cancer therapeutic development. British Journal of Pharmacology, 169 (4): 719–735., which has been published in final form at http://dx.doi.org/10.1111/bph.12155. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
You might also like
Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs
(2017)
Journal Article
Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors
(2016)
Journal Article
Oncology Activity
(2016)
Book Chapter
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search