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Non-invasive molecular imaging for preclinical cancer therapeutic development

O'Farrell, AC; Shnyder, SD; Marston, G; Colletta, L; Gill, JH

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Authors

AC O'Farrell

SD Shnyder

G Marston

L Colletta

JH Gill



Abstract

Molecular and non-invasive imaging are rapidly emerging fields in preclinical cancer drug discovery. This is driven by the need to develop more efficacious and safer treatments, the advent of molecular targeted therapeutics, and the requirements to reduce and refine current preclinical in vivo models. Such bioimaging strategies include magnetic resonance imaging (MRI), positron emission tomography (PET), single positron emission computed tomography (SPECT), ultrasound, and optical approaches such as bioluminescence and fluorescence imaging. These molecular imaging modalities have several advantages over traditional screening methods, not least the ability to quantitatively monitor pharmacodynamic changes at the cellular and molecular level in living animals non-invasively in real-time. This review aims to provide an overview of non-invasive molecular imaging techniques, highlighting the strengths, limitations and versatility of these approaches in preclinical cancer drug discovery and development.

Citation

O'Farrell, A., Shnyder, S., Marston, G., Colletta, L., & Gill, J. (2013). Non-invasive molecular imaging for preclinical cancer therapeutic development. British Journal of Pharmacology, 169(4), 719-735. https://doi.org/10.1111/bph.12155

Journal Article Type Article
Publication Date Jun 1, 2013
Deposit Date Mar 4, 2013
Publicly Available Date May 23, 2013
Journal British Journal of Pharmacology
Print ISSN 0007-1188
Electronic ISSN 1476-5381
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 169
Issue 4
Pages 719-735
DOI https://doi.org/10.1111/bph.12155
Keywords Non-invasive imaging, Cancer Pharmacology, Bioluminescence, Ultrasound, Positron Emission Tomography (PET), Magnetic resonance imaging (MRI).

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Copyright Statement
This is the peer reviewed version of the following article: O'Farrell, A., Shnyder, S., Marston, G., Coletta, P. and Gill, J. (2013), Non-invasive molecular imaging for preclinical cancer therapeutic development. British Journal of Pharmacology, 169 (4): 719–735., which has been published in final form at http://dx.doi.org/10.1111/bph.12155. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.




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