Reduction of alkyl and aryl azides with sodium thiophosphate in aqueous solutions

Norcliffe, J.L.; Conway, L.P.; Hodgson, D.R.W.

doi:10.1016/j.tetlet.2011.03.083

Reduction of alkyl and aryl azides with sodium thiophosphate in aqueous solutions

Norcliffe, J.L.; Conway, L.P.; Hodgson, D.R.W.

Authors

J.L. Norcliffe

L.P. Conway

Professor David Hodgson d.r.w.hodgson@durham.ac.uk
Professor

Abstract

A simple aqueous method for the conversion of alkyl and aryl azides into the corresponding amines using trisodium thiophosphate is presented. Thiophosphate is converted into phosphate during these formal reduction processes.

Citation

Norcliffe, J., Conway, L., & Hodgson, D. (2011). Reduction of alkyl and aryl azides with sodium thiophosphate in aqueous solutions. Tetrahedron Letters, 52(21), 2730-2732. https://doi.org/10.1016/j.tetlet.2011.03.083

Journal Article Type	Article
Publication Date	May 1, 2011
Deposit Date	Feb 6, 2012
Publicly Available Date	May 22, 2013
Journal	Tetrahedron Letters
Print ISSN	0040-4039
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	52
Issue	21
Pages	2730-2732
DOI	https://doi.org/10.1016/j.tetlet.2011.03.083
Keywords	Aqueous, Azide, Reduction, Thiophosphate

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Copyright Statement
NOTICE: this is the author’s version of a work that was accepted for publication in Tetrahedron letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron letters, 52 (21), 2011, 10.1016/j.tetlet.2011.03.083