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The importance of mosquito behavioural adaptations to malaria control in Africa

Gatton, M.; Chitnis, N.; Churcher, T.; Donnelly, M.J.; Ghani, A.C.; Godfray, C.J.; Gould, F.; Hastings, I.; Marshall, J.; Ranson, H.; Rowland, R.; Shaman, J.; Lindsay, S.W.

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Authors

M. Gatton

N. Chitnis

T. Churcher

M.J. Donnelly

A.C. Ghani

C.J. Godfray

F. Gould

I. Hastings

J. Marshall

H. Ranson

R. Rowland

J. Shaman



Abstract

Over the past decade the use of long-lasting insecticidal nets (LLINs), in combination with improved drug therapies, indoor residual spraying (IRS), and better health infrastructure, has helped reduce malaria in many African countries for the first time in a generation. However, insecticide resistance in the vector is an evolving threat to these gains. We review emerging and historical data on behavioral resistance in response to LLINs and IRS. Overall the current literature suggests behavioral and species changes may be emerging, but the data are sparse and, at times unconvincing. However, preliminary modeling has demonstrated that behavioral resistance could have significant impacts on the effectiveness of malaria control. We propose seven recommendations to improve understanding of resistance in malaria vectors. Determining the public health impact of physiological and behavioral insecticide resistance is an urgent priority if we are to maintain the significant gains made in reducing malaria morbidity and mortality.

Citation

Gatton, M., Chitnis, N., Churcher, T., Donnelly, M., Ghani, A., Godfray, C., …Lindsay, S. (2013). The importance of mosquito behavioural adaptations to malaria control in Africa. Evolution: International Journal of Organic Evolution, 67(4), 1218-1230. https://doi.org/10.1111/evo.12063

Journal Article Type Article
Publication Date Apr 1, 2013
Deposit Date Apr 10, 2013
Publicly Available Date Mar 28, 2024
Journal Evolution
Print ISSN 0014-3820
Electronic ISSN 1558-5646
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 67
Issue 4
Pages 1218-1230
DOI https://doi.org/10.1111/evo.12063
Keywords Anopheles, Indoor residual spraying, Insecticidal nets, Resistance.

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Copyright Statement
This is the peer reviewed version of the following article: Gatton, M.L., Chitnis, N., Churcher, T., Donnelly, M.J., Ghani, A.C., Godfray, H.C.J., Gould, F., Hastings, I., Marshall, J., Ranson, H., Rowland, M., Shaman, J. and Lindsay, S.W. (2013). The importance of mosquito behavioural adaptations to malaria control in Africa. Evolution 67(4): 1218-1230., which has been published in final form at http://dx.doi.org/10.1111/evo.12063. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.





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