Investigating the micro-rheology of the vitreous humor using an optically trapped local probe

Watts, Fiona; Tan, Lay Ean; Wilson, Clive G.; Girkin, John M.; Tassieri, Manlio; Wright, Amanda Jane

doi:10.1088/2040-8978/16/1/015301

Investigating the micro-rheology of the vitreous humor using an optically trapped local probe

Watts, Fiona; Tan, Lay Ean; Wilson, Clive G.; Girkin, John M.; Tassieri, Manlio; Wright, Amanda Jane

Authors

Fiona Watts

Lay Ean Tan

Clive G. Wilson

Professor John Girkin j.m.girkin@durham.ac.uk
Professor

Manlio Tassieri

Amanda Jane Wright

Abstract

We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.

Citation

Watts, F., Tan, L. E., Wilson, C. G., Girkin, J. M., Tassieri, M., & Wright, A. J. (2014). Investigating the micro-rheology of the vitreous humor using an optically trapped local probe. Journal of Optics, 16(1), https://doi.org/10.1088/2040-8978/16/1/015301

Journal Article Type	Article
Publication Date	Jan 1, 2014
Deposit Date	May 22, 2014
Publicly Available Date	May 26, 2014
Journal	Journal of Optics
Print ISSN	2040-8978
Electronic ISSN	2040-8986
Publisher	IOP Publishing
Peer Reviewed	Peer Reviewed
Volume	16
Issue	1
DOI	https://doi.org/10.1088/2040-8978/16/1/015301
Keywords	Optical trapping, Micro-rheology, Vitreous humor.

Files

Published Journal Article (691 Kb)
PDF

Copyright Statement
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.