Pd-catalysed sp2-sp cross-coupling reactions involving aromatic C-F bond activation in highly fluorinated nitrobenzene systems

Cargill, M.R.; Sandford, G.; Kilickiran, P.; Nelles, G.

doi:10.1016/j.tet.2012.11.031

Pd-catalysed sp2-sp cross-coupling reactions involving aromatic C-F bond activation in highly fluorinated nitrobenzene systems

Cargill, M.R.; Sandford, G.; Kilickiran, P.; Nelles, G.

Authors

M.R. Cargill

G. Sandford

P. Kilickiran

G. Nelles

Abstract

Direct and regioselective alkynylation of highly fluorinated nitrobenzene derivatives by palladium-catalyzed Sonogashira type processes is described, representing the first examples of metal-catalyzed sp2–sp cross-coupling reactions involving C–F bond activation.

Citation

Cargill, M., Sandford, G., Kilickiran, P., & Nelles, G. (2013). Pd-catalysed sp2-sp cross-coupling reactions involving aromatic C-F bond activation in highly fluorinated nitrobenzene systems. Tetrahedron, 69(2), 512-516. https://doi.org/10.1016/j.tet.2012.11.031

Journal Article Type	Article
Publication Date	Jan 14, 2013
Deposit Date	May 21, 2014
Publicly Available Date	May 29, 2014
Journal	Tetrahedron
Print ISSN	0040-4020
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	69
Issue	2
Pages	512-516
DOI	https://doi.org/10.1016/j.tet.2012.11.031

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Copyright Statement
NOTICE: this is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron, 69, 2, 2013, 10.1016/j.tet.2012.11.031.