J.A Hickin
The synthesis and structure revision of NSC-134754
Hickin, J.A; Ahmed, A; Fucke, K; Ashcroft, M; Jones, K
Authors
A Ahmed
K Fucke
M Ashcroft
K Jones
Abstract
The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF.
Citation
Hickin, J., Ahmed, A., Fucke, K., Ashcroft, M., & Jones, K. (2014). The synthesis and structure revision of NSC-134754. Chemical Communications, 50(10), 1238-1240. https://doi.org/10.1039/c3cc48189a
| Journal Article Type | Article |
|---|---|
| Publication Date | Jan 1, 2014 |
| Deposit Date | Sep 2, 2014 |
| Journal | Chemical Communications |
| Print ISSN | 1359-7345 |
| Electronic ISSN | 1364-548X |
| Publisher | Royal Society of Chemistry |
| Peer Reviewed | Peer Reviewed |
| Volume | 50 |
| Issue | 10 |
| Pages | 1238-1240 |
| DOI | https://doi.org/10.1039/c3cc48189a |
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