Synthesis of 4,4-difluoro-1H-pyrazole derivatives

Breen, J.R.; Sandford, G.; Patel, B.; Fray, J.

doi:10.1055/s-0034-1378915

Synthesis of 4,4-difluoro-1H-pyrazole derivatives

Breen, J.R.; Sandford, G.; Patel, B.; Fray, J.

Authors

J.R. Breen

G. Sandford

B. Patel

J. Fray

Abstract

Fluorination of 3,5-diarylpyrazole substrates by SelectfluorTM in acetonitrile gave 4,4-difluoro-1H-pyrazoles in addition to 4-fluoropyrazole derivatives. The structure of this new class of fluorinated heterocycle was established by X-ray crystallography.

Citation

Breen, J., Sandford, G., Patel, B., & Fray, J. (2015). Synthesis of 4,4-difluoro-1H-pyrazole derivatives. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 26(01), 51-54. https://doi.org/10.1055/s-0034-1378915

Journal Article Type	Article
Publication Date	Jan 1, 2015
Deposit Date	Nov 13, 2014
Publicly Available Date	Nov 21, 2014
Journal	Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
Print ISSN	0936-5214
Electronic ISSN	1437-2096
Publisher	Thieme Gruppe
Peer Reviewed	Peer Reviewed
Volume	26
Issue	01
Pages	51-54
DOI	https://doi.org/10.1055/s-0034-1378915
Keywords	Organofluorine, Fluoroheterocycle, Pyrazole, Selective fluorination, Fluoropyrazole.