Hippocampal synaptic plasticity, spatial memory and anxiety

Bannerman, D. M.; Sprengel, R.; Sanderson, D. J.; McHugh, S. B.; Rawlins, J. N. P.; Monyer, H.; Seeburg, P. H.

doi:10.1038/nrn3677

Hippocampal synaptic plasticity, spatial memory and anxiety

Bannerman, D. M.; Sprengel, R.; Sanderson, D. J.; McHugh, S. B.; Rawlins, J. N. P.; Monyer, H.; Seeburg, P. H.

Authors

D. M. Bannerman

R. Sprengel

Professor David Sanderson david.sanderson@durham.ac.uk
Professor

S. B. McHugh

J. N. P. Rawlins

H. Monyer

P. H. Seeburg

Abstract

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

Citation

Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014). Hippocampal synaptic plasticity, spatial memory and anxiety. Nature Reviews Neuroscience, 15(3), 181-192. https://doi.org/10.1038/nrn3677

Journal Article Type	Article
Online Publication Date	Feb 20, 2014
Publication Date	Mar 1, 2014
Deposit Date	Feb 20, 2014
Publicly Available Date	Dec 19, 2014
Journal	Nature Reviews Neuroscience
Print ISSN	1471-003X
Electronic ISSN	1471-0048
Publisher	Nature Research
Peer Reviewed	Peer Reviewed
Volume	15
Issue	3
Pages	181-192
DOI	https://doi.org/10.1038/nrn3677
Public URL	https://durham-repository.worktribe.com/output/1436606