Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups

Joubert, Fanny; Sharples, Gary J.; Musa, Osama M.; Hodgson, David R.W.; Cameron, Neil R.

doi:10.1002/pola.27441

Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups

Joubert, Fanny; Sharples, Gary J.; Musa, Osama M.; Hodgson, David R.W.; Cameron, Neil R.

Authors

Fanny Joubert

Dr Gary Sharples gary.sharples@durham.ac.uk
Associate Professor

Osama M. Musa

Professor David Hodgson d.r.w.hodgson@durham.ac.uk
Professor

Neil R. Cameron

Abstract

Lactam groups were introduced onto the backbone of hydroxyethyl cellulose (HEC) to modify properties, such as solubility in organic solvents and solution viscosity and to introduce possible antibacterial activity. Functionalization was achieved using 1-(hydroxymethyl)-2-pyrrolidinone (HMP), and the functionalization reactions were investigated using NMR spectroscopy. The covalent attachment between HEC and HMP was confirmed using 1H-13C correlated NMR experiments. Degrees of functionalization were calculated using integrated 13C NMR spectra, with values of up to 0.9 being demonstrated on the primary alcohol functionality of HEC. The functionalized HECs showed markedly different properties to unfunctionalized HEC, including the ability to swell considerably in water. Functionalized HEC displayed increased thermal stability and reduced solution viscosity compared with unfunctionalized HEC. Moreover, functionalization altered the bacterial adhesion characteristics compared with unfunctionalized HEC.

Citation

Joubert, F., Sharples, G. J., Musa, O. M., Hodgson, D. R., & Cameron, N. R. (2015). Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups. Journal of Polymer Science Part A: Polymer Chemistry, 53(1), 68-78. https://doi.org/10.1002/pola.27441

Journal Article Type	Article
Acceptance Date	Oct 5, 2014
Online Publication Date	Oct 29, 2014
Publication Date	Jan 1, 2015
Deposit Date	Dec 10, 2014
Publicly Available Date	Jan 21, 2015
Journal	Journal of Polymer Science Part A: Polymer Chemistry
Print ISSN	0887-624X
Electronic ISSN	1099-0518
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	53
Issue	1
Pages	68-78
DOI	https://doi.org/10.1002/pola.27441
Keywords	Biopolymers, Modification, Polysaccharides, Synthesis.

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© 2014 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.