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Furosemide cocrystals : structures, hydrogen bonding, and implications for properties.

Harriss, Bethany I. and Vella-Zarb, Liana and Wilson, Claire and Evans, Ivana R. (2014) 'Furosemide cocrystals : structures, hydrogen bonding, and implications for properties.', Crystal growth and design., 14 (2). pp. 783-791.

Abstract

Four new crystal structures of pharmaceutical molecule furosemide with GRAS coformers are reported and correlated with the known pharmacologically relevant properties of these materials. Furosemide carboxylic acid oxygen donor−coformer aromatic nitrogen acceptor is the dominant synthon, leading to the key intermolecular interactions in the cocrystals studied.

Item Type:Article
Full text:(AM) Accepted Manuscript
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Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1021/cg401662d
Publisher statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal growth and design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://dx.doi.org/10.1021/cg401662d
Record Created:28 Jan 2015 11:20
Last Modified:31 Jul 2015 15:26

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