Furosemide Cocrystals: Structures, Hydrogen Bonding, and Implications for Properties

Harriss, Bethany I.; Vella-Zarb, Liana; Wilson, Claire; Radosavljevic Evans, Ivana

doi:10.1021/cg401662d

Furosemide Cocrystals: Structures, Hydrogen Bonding, and Implications for Properties

Harriss, Bethany I.; Vella-Zarb, Liana; Wilson, Claire; Radosavljevic Evans, Ivana

Authors

Bethany I. Harriss

Liana Vella-Zarb

Claire Wilson

Ivana Radosavljevic Evans

Contributors

Professor Ivana Evans ivana.radosavljevic@durham.ac.uk
Other

Abstract

Four new crystal structures of pharmaceutical molecule furosemide with GRAS coformers are reported and correlated with the known pharmacologically relevant properties of these materials. Furosemide carboxylic acid oxygen donor−coformer aromatic nitrogen acceptor is the dominant synthon, leading to the key intermolecular interactions in the cocrystals studied.

Citation

Harriss, B. I., Vella-Zarb, L., Wilson, C., & Radosavljevic Evans, I. (2014). Furosemide Cocrystals: Structures, Hydrogen Bonding, and Implications for Properties. Crystal Growth and Design, 14(2), 783-791. https://doi.org/10.1021/cg401662d

Journal Article Type	Article
Publication Date	Feb 5, 2014
Deposit Date	Oct 21, 2014
Publicly Available Date	Jan 28, 2015
Journal	Crystal Growth and Design
Print ISSN	1528-7483
Electronic ISSN	1528-7505
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	14
Issue	2
Pages	783-791
DOI	https://doi.org/10.1021/cg401662d

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal growth and design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://dx.doi.org/10.1021/cg401662d