Nickel recognition by bacterial importer proteins

Chivers, P.T.

doi:10.1039/c4mt00310a

Nickel recognition by bacterial importer proteins

Chivers, P.T.

Authors

Dr Peter Chivers peter.chivers@durham.ac.uk
Associate Professor

Abstract

Nickel supports the growth of microbes from a variety of very different growth environments that affect nickel speciation. The mechanisms of nickel uptake and the molecular bases for the selectivity of this process are emerging. The recent surge of Ni-importer protein structures provides an understanding of Ni-recognition in the initial binding step of the import process. This review compares the structural basis for Ni-recognition in the complexes (ABC and ECF-type) that dominate primary (ATP-dependent) transport, with a focus on how the structures suggest mechanisms for Ni selectivity. The structures raise key questions about the mechanisms of nickel-transfer reactions involved in import. There is also a discussion of key experimental approaches necessary to help establish the physiological importance of these structures.

Citation

Chivers, P. (2015). Nickel recognition by bacterial importer proteins. Metallomics, 7(4), 590-595. https://doi.org/10.1039/c4mt00310a

Journal Article Type	Article
Acceptance Date	Jan 20, 2015
Publication Date	Apr 20, 2015
Deposit Date	Jan 30, 2015
Publicly Available Date	Feb 10, 2015
Journal	Metallomics
Print ISSN	1756-5901
Electronic ISSN	1756-591X
Publisher	Oxford University Press
Peer Reviewed	Peer Reviewed
Volume	7
Issue	4
Pages	590-595
DOI	https://doi.org/10.1039/c4mt00310a