Skip to main content

Research Repository

Advanced Search

Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

Harsanyi, A.; Sandford, G.

Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters Thumbnail


Authors

A. Harsanyi

G. Sandford



Abstract

Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.

Citation

Harsanyi, A., & Sandford, G. (2015). Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters. Green Chemistry, 17(5), 3000-3009. https://doi.org/10.1039/c5gc00402k

Journal Article Type Article
Acceptance Date Mar 17, 2015
Online Publication Date Mar 17, 2015
Publication Date May 1, 2015
Deposit Date Apr 1, 2015
Publicly Available Date Mar 28, 2024
Journal Green Chemistry
Print ISSN 1463-9262
Electronic ISSN 1463-9270
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 17
Issue 5
Pages 3000-3009
DOI https://doi.org/10.1039/c5gc00402k

Files

Accepted Journal Article (1.4 Mb)
PDF

Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.





You might also like



Downloadable Citations