A. Harsanyi
Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters
Harsanyi, A.; Sandford, G.
Authors
G. Sandford
Abstract
Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.
Citation
Harsanyi, A., & Sandford, G. (2015). Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters. Green Chemistry, 17(5), 3000-3009. https://doi.org/10.1039/c5gc00402k
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 17, 2015 |
Online Publication Date | Mar 17, 2015 |
Publication Date | May 1, 2015 |
Deposit Date | Apr 1, 2015 |
Publicly Available Date | Mar 28, 2024 |
Journal | Green Chemistry |
Print ISSN | 1463-9262 |
Electronic ISSN | 1463-9270 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 17 |
Issue | 5 |
Pages | 3000-3009 |
DOI | https://doi.org/10.1039/c5gc00402k |
Files
Accepted Journal Article
(1.4 Mb)
PDF
Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Published Journal Article
(1.1 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
You might also like
HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF3-ynones
(2020)
Journal Article
Kinetics of electrophilic fluorination of steroids and epimerisation of fluorosteroids
(2020)
Journal Article
Fluorocyanoesters as Additives for Lithium-Ion Battery Electrolytes
(2020)
Journal Article
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search