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A procedure for the preparation and isolation of nucleoside-5’-diphosphates.

Korhonen, H. J. and Bolt, H. L. and Hodgson, D. R. W. (2015) 'A procedure for the preparation and isolation of nucleoside-5’-diphosphates.', Beilstein journal of organic chemistry., 11 . pp. 469-472.


Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5’-diphosphates from crude reaction mixtures.

Item Type:Article
Keywords:NDP synthesis, Nucleic acids, Nucleoside-5’-diphosphate, Phosphorylation.
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Publisher statement:© 2015 Korhonen et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date accepted:25 March 2015
Date deposited:14 April 2015
Date of first online publication:April 2015
Date first made open access:No date available

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