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Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation

Sadler, S.A.; Hones, A.C.; Roberts, B.; Blakemore, D.C.; Marder, T.B.; Steel, P.G.

Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation Thumbnail


Authors

S.A. Sadler

A.C. Hones

B. Roberts

D.C. Blakemore

T.B. Marder



Abstract

In the absence of a steric directing group, iridium-catalyzed C–H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C–H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.

Citation

Sadler, S., Hones, A., Roberts, B., Blakemore, D., Marder, T., & Steel, P. (2015). Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation. Journal of Organic Chemistry, 80(10), 5308-5314. https://doi.org/10.1021/acs.joc.5b00452

Journal Article Type Article
Acceptance Date May 12, 2015
Publication Date May 15, 2015
Deposit Date May 12, 2015
Publicly Available Date Mar 29, 2024
Journal Journal of Organic Chemistry
Print ISSN 0022-3263
Electronic ISSN 1520-6904
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 80
Issue 10
Pages 5308-5314
DOI https://doi.org/10.1021/acs.joc.5b00452

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © 2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.joc.5b00452.





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