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Evidence-based vector control? Improving the quality of vector control trials.

Wilson, A.L. and Boelaert, M. and Kleinschmidt, I. and Pinder, M. and Scott, T.W. and Tusting, L.S. and Lindsay, S.W. (2015) 'Evidence-based vector control? Improving the quality of vector control trials.', Trends in parasitology., 31 (8). pp. 380-390.

Abstract

Vector-borne diseases (VBDs) such as malaria, dengue, and leishmaniasis cause a high level of morbidity and mortality. Although vector control tools can play a major role in controlling and eliminating these diseases, in many cases the evidence base for assessing the efficacy of vector control interventions is limited or not available. Studies assessing the efficacy of vector control interventions are often poorly conducted, which limits the return on investment of research funding. Here we outline the principal design features of Phase III vector control field studies, highlight major failings and strengths of published studies, and provide guidance on improving the design and conduct of vector control studies. We hope that this critical assessment will increase the impetus for more carefully considered and rigorous design of vector control studies.

Item Type:Article
Keywords:Vector-borne disease, Vector control, Phase III trials, Research design / standards.
Full text:(VoR) Version of Record
Available under License - Creative Commons Attribution.
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Full text:(VoR) Version of Record
Available under License - Creative Commons Attribution.
Download PDF (Final published version)
(700Kb)
Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1016/j.pt.2015.04.015
Publisher statement:© 2015 Durham University. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). http:// dx.doi.org/10.1016/j.pt.2015.04.015.
Record Created:26 May 2015 10:05
Last Modified:02 Sep 2015 10:55

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