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Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations

Alderson-Day, B.; McCarthy-Jones, S.; Fernyhough, C.

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Authors

S. McCarthy-Jones



Abstract

Resting state networks (RSNs) are thought to reflect the intrinsic functional connectivity of brain regions. Alterations to RSNs have been proposed to underpin various kinds of psychopathology, including the occurrence of auditory verbal hallucinations (AVH). This review outlines the main hypotheses linking AVH and the resting state, and assesses the evidence for alterations to intrinsic connectivity provided by studies of resting fMRI in AVH. The influence of hallucinations during data acquisition, medication confounds, and movement are also considered. Despite a large variety of analytic methods and designs being deployed, it is possible to conclude that resting connectivity in the left temporal lobe in general and left superior temporal gyrus in particular are disrupted in AVH. There is also preliminary evidence of atypical connectivity in the default mode network and its interaction with other RSNs. Recommendations for future research include the adoption of a common analysis protocol to allow for more overlapping datasets and replication of intrinsic functional connectivity alterations.

Citation

Alderson-Day, B., McCarthy-Jones, S., & Fernyhough, C. (2015). Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations. Neuroscience & Biobehavioral Reviews, 55, 78-87. https://doi.org/10.1016/j.neubiorev.2015.04.016

Journal Article Type Article
Acceptance Date Apr 25, 2015
Online Publication Date May 5, 2015
Publication Date Aug 1, 2015
Deposit Date Apr 26, 2015
Publicly Available Date Jun 1, 2015
Journal Neuroscience and Biobehavioral Reviews
Print ISSN 0149-7634
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 55
Pages 78-87
DOI https://doi.org/10.1016/j.neubiorev.2015.04.016
Keywords Resting state, Default mode network, Voice-hearing, Inner speech, Schizophrenia.

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