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To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia : study protocol for a two-armed cluster-randomised study.

Pinder, M. and Jawara, M. and Jarju, L.B.S. and Ballah, K. and Jeffries, D. and Lluberas, M.F. and Mueller, J. and Parker, D. and Conway, D.J. and Lindsay, S.W. (2011) 'To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia : study protocol for a two-armed cluster-randomised study.', Trials., 12 . p. 147.

Abstract

Background: Recently, there has been mounting interest in scaling-up vector control against malaria in Africa. It needs to be determined if indoor residual spraying (IRS with DDT) will provide significant marginal protection against malaria over current best practice of long-lasting insecticidal nets (LLINs) and prompt treatment in a controlled trial, given that DDT is currently the most persistent insecticide for IRS. Methods: A 2 armed cluster-randomised controlled trial will be conducted to assess whether DDT IRS and LLINs combined provide better protection against clinical malaria in children than LLINs alone in rural Gambia. Each cluster will be a village, or a group of small adjacent villages; all clusters will receive LLINs and half will receive IRS in addition. Study children, aged 6 months to 13 years, will be enrolled from all clusters and followed for clinical malaria using passive case detection to estimate malaria incidence for 2 malaria transmission seasons in 2010 and 2011. This will be the primary endpoint. Exposure to malaria parasites will be assessed using light and exit traps followed by detection of Anopheles gambiae species and sporozoite infection. Study children will be surveyed at the end of each transmission season to estimate the prevalence of Plasmodium falciparum infection and the prevalence of anaemia. Discussion: Practical issues concerning intervention implementation, as well as the potential benefits and risks of the study, are discussed. Trial Registration: ISRCTN01738840 - Spraying And Nets Towards malaria Elimination (SANTE)

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Status:Peer-reviewed
Publisher Web site:http://dx.doi.org/10.1186/1745-6215-12-147
Publisher statement:© 2011 Pinder et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Record Created:09 Jun 2015 11:35
Last Modified:09 Jun 2015 14:14

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