Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators

Seemann, J.; Waldron, B.P.; Roesch, F.; Parker, D.

doi:10.1002/cmdc.201500092

Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators

Seemann, J.; Waldron, B.P.; Roesch, F.; Parker, D.

Authors

J. Seemann

B.P. Waldron

F. Roesch

Professor David Parker david.parker@durham.ac.uk
Emeritus Professor

Abstract

The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of 68Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO3A, and DO2A derivatives), DATA chelators undergo quantitative radiolabelling more rapidly and under milder conditions. In this study, a systematic evaluation of the labelling of four DATA chelators—DATAM, DATAP, DATAPh, and DATAPPh—with 68Ga is presented. The results highlight the extraordinary potential of this new class of chelators for application in molecular imaging using 68Ga positron emission tomography (PET).

Citation

Seemann, J., Waldron, B., Roesch, F., & Parker, D. (2015). Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators. ChemMedChem, 10(6), 1019-1026. https://doi.org/10.1002/cmdc.201500092

Journal Article Type	Article
Online Publication Date	Apr 21, 2015
Publication Date	Jun 1, 2015
Deposit Date	Jul 20, 2015
Publicly Available Date	Apr 21, 2016
Journal	ChemMedChem
Print ISSN	1860-7179
Electronic ISSN	1860-7187
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	10
Issue	6
Pages	1019-1026
DOI	https://doi.org/10.1002/cmdc.201500092
Keywords	Chelates, Gallium-68, Ligand design, Macrocyclic ligands, Radiopharmaceuticals.

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Copyright Statement
This is the peer reviewed version of the following article: FSeemann, J., Waldron, B. P., Roesch, F. and Parker, D. (2015), Approaching ‘Kit-Type’ Labelling with 68Ga: The DATA Chelators. ChemMedChem, 10(6): 1019-1026, which has been published in final form at http://dx.doi.org/10.1002/cmdc.201500092. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.