A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component

Baxendale, I.R.

doi:10.1002/ceat.201500255

A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component

Baxendale, I.R.

Authors

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Abstract

The search for novel chemical architectures displaying improved biological properties is a never-ending synthetic challenge. In this context many new test structures are often conceived by selecting and replicating specific design elements from naturally occurring molecules and displaying them in an alternative format by way of a new chemical assembly. Constructing these newly designed compounds can be a timely and expensive process especially when a large quantity of the target material is required for physiochemical and property testing. To permit easier scale-up and safer working practice, many chemical researchers are employing flow chemistry approaches to aid in their synthesis challenges. The preparation of a key spirocyclic lactone using flow-based reaction processing techniques is reported.

Citation

Baxendale, I. (2015). A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component. Chemical Engineering & Technology, 38(10), 1713-1716. https://doi.org/10.1002/ceat.201500255

Journal Article Type	Article
Acceptance Date	Jul 30, 2015
Online Publication Date	Sep 10, 2015
Publication Date	Oct 1, 2015
Deposit Date	Aug 21, 2015
Publicly Available Date	Aug 3, 2016
Journal	Chemical Engineering and Technology
Print ISSN	0930-7516
Electronic ISSN	1521-4125
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	38
Issue	10
Pages	1713-1716
DOI	https://doi.org/10.1002/ceat.201500255
Keywords	Flow synthesis, Meso reactor, Multi-step, Diels Alder reaction, Baylis Hillman reaction.

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Copyright Statement
This is the peer reviewed version of the following article: Baxendale, I. R. (2015) 'A short multi-step flow synthesis of a potential spirocyclic fragrance component.', Chemical engineering and technology. 38(10: 1713-1716, which has been published in final form at http://dx.doi.org/10.1002/ceat.201500255. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.