T.C.B. McLeish
Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?
McLeish, T.C.B.; Cann, M.J.; Rodgers, T.L.
Abstract
We examine the contrast between mechanisms for allosteric signaling that involve structural change, and those that do not, from the perspective of allosteric pathways. In particular we treat in detail the case of fluctuation-allostery by which amplitude modulation of the thermal fluctuations of the elastic normal modes conveys the allosteric signal, and address the question of what an allosteric pathway means in this case. We find that a perturbation theory of thermal elastic solids and nonperturbative approach (by super-coarse-graining elasticity into internal bending modes) have opposite signatures in their structure of correlated pathways. We illustrate the effect from analysis of previous results from GlxR of Corynebacterium glutamicum, an example of the CRP/FNR transcription family of allosteric homodimers. We find that the visibility of both correlated pathways and disconnected sites of correlated motion in this protein suggests that mechanisms of local elastic stretch and bend are recruited for the purpose of creating and controlling allosteric cooperativity.
Citation
McLeish, T., Cann, M., & Rodgers, T. (2015). Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?. Biophysical Journal, 109(6), 1240-1250. https://doi.org/10.1016/j.bpj.2015.08.009
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 7, 2015 |
Online Publication Date | Aug 31, 2015 |
Publication Date | Sep 15, 2015 |
Deposit Date | Sep 18, 2015 |
Publicly Available Date | Aug 31, 2016 |
Journal | Biophysical Journal |
Print ISSN | 0006-3495 |
Publisher | Biophysical Society |
Peer Reviewed | Peer Reviewed |
Volume | 109 |
Issue | 6 |
Pages | 1240-1250 |
DOI | https://doi.org/10.1016/j.bpj.2015.08.009 |
Files
Accepted Journal Article
(1.6 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Statement
© 2015 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
You might also like
Trepidation or Precession: The Turning Point in a Tradition
(2023)
Book Chapter
Commentary on the model of the world machine
(2023)
Book Chapter
The ‘allosteron’ model for entropic allostery of self-assembly
(2018)
Journal Article
Unity and Symmetry in the De Luce of Robert Grosseteste
(2016)
Book Chapter
Elasticity dominated surface segregation of small molecules in polymer mixtures
(2016)
Journal Article
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search