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Bioresponsive hydrogels

Ulijn, R.V.; Bibi, N.; Jayawarna, V.; Thornton, P.D.; Todd, S.J.; Mart, R.J.; Smith, A.M.; Gough, J.E.

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Authors

R.V. Ulijn

N. Bibi

V. Jayawarna

P.D. Thornton

S.J. Todd

R.J. Mart

A.M. Smith

J.E. Gough



Abstract

We highlight recent developments in hydrogel materials with biological responsiveness built in. These ‘smart’ biomaterials change properties in response to selective biological recognition events. When exposed to a biological target (nutrient, growth factor, receptor, antibody, enzyme, or whole cell), molecular recognition events trigger changes in molecular interactions that translate into macroscopic responses, such as swelling/collapse or solution-to-gel transitions. The hydrogel transitions may be used directly as optical readouts for biosensing, linked to the release of actives for drug delivery, or instigate biochemical signaling events that control or direct cellular behavior. Accordingly, bioresponsive hydrogels have gained significant interest for application in diagnostics, drug delivery, and tissue regeneration/wound healing.

Citation

Ulijn, R., Bibi, N., Jayawarna, V., Thornton, P., Todd, S., Mart, R., …Gough, J. (2007). Bioresponsive hydrogels. Materials Today, 10(4), 40-48. https://doi.org/10.1016/s1369-7021%2807%2970049-4

Journal Article Type Article
Publication Date Apr 1, 2007
Deposit Date Aug 1, 2012
Publicly Available Date Sep 22, 2015
Journal Materials Today
Print ISSN 1369-7021
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 10
Issue 4
Pages 40-48
DOI https://doi.org/10.1016/s1369-7021%2807%2970049-4

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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
© Elsevier Ltd 2007 Open access under CC BY-NC-ND license. This article is published under the terms of the Creative Commons Attribution-NonCommercial-No Derivatives License (CC BY NC ND). For non-commercial purposes you may distribute and copy the article and include it in a collective work (such as an anthology), provided you do not alter or modify the article, without permission from Elsevier. The original work must always be appropriately credited. Permission is not required for this non-commercial use. For commercial use please continue to request permission via RightsLink.




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