Total syntheses of natural products containing spirocarbocycles

Smith, L.K.; Baxendale, I.R.

doi:10.1039/c5ob01524c

Total syntheses of natural products containing spirocarbocycles

Smith, L.K.; Baxendale, I.R.

Authors

L.K. Smith

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Abstract

The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring closure which we examine in this review.

Citation

Smith, L., & Baxendale, I. (2015). Total syntheses of natural products containing spirocarbocycles. Organic and Biomolecular Chemistry, 13(39), 9907-9933. https://doi.org/10.1039/c5ob01524c

Journal Article Type	Article
Acceptance Date	Sep 1, 2015
Publication Date	Oct 21, 2015
Deposit Date	Sep 17, 2015
Publicly Available Date	Sep 1, 2016
Journal	Organic and Biomolecular Chemistry
Print ISSN	1477-0520
Electronic ISSN	1477-0539
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	13
Issue	39
Pages	9907-9933
DOI	https://doi.org/10.1039/c5ob01524c