Controlled Flow Precipitation as a Valuable Tool for Synthesis

Filipponi, Paolo; Gioiello, Antimo; Baxendale, Ian R.

doi:10.1021/acs.oprd.5b00331

Controlled Flow Precipitation as a Valuable Tool for Synthesis

Filipponi, Paolo; Gioiello, Antimo; Baxendale, Ian R.

Authors

Paolo Filipponi

Antimo Gioiello

Professor Ian Baxendale i.r.baxendale@durham.ac.uk
Professor

Abstract

In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an important area of research. In this article we demonstrate how a dynamically agitated flow reactor can be a powerful tool to facilitate workup and processing of biphasic solid–liquid flow streams at scale.

Citation

Filipponi, P., Gioiello, A., & Baxendale, I. R. (2016). Controlled Flow Precipitation as a Valuable Tool for Synthesis. Organic Process Research and Development, 20(2), 371-375. https://doi.org/10.1021/acs.oprd.5b00331

Journal Article Type	Article
Acceptance Date	Oct 17, 2015
Online Publication Date	Nov 17, 2015
Publication Date	Feb 19, 2016
Deposit Date	Nov 20, 2015
Publicly Available Date	Nov 17, 2016
Journal	Organic Process Research and Development
Print ISSN	1083-6160
Electronic ISSN	1520-586X
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	20
Issue	2
Pages	371-375
DOI	https://doi.org/10.1021/acs.oprd.5b00331

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Process Research & Development, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.oprd.5b00331.