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Zero-inflated regression models for radiation-induced chromosome aberration data: A comparative study

Oliveira, María; Einbeck, Jochen; Higueras, Manuel; Ainsbury, Elizabeth; Puig, Pedro; Rothkamm, Kai

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Authors

María Oliveira

Manuel Higueras

Elizabeth Ainsbury

Pedro Puig

Kai Rothkamm



Abstract

Within the field of cytogenetic biodosimetry, Poisson regression is the classical approach for modeling the number of chromosome aberrations as a function of radiation dose. However, it is common to find data that exhibit overdispersion. In practice, the assumption of equidispersion may be violated due to unobserved heterogeneity in the cell population, which will render the variance of observed aberration counts larger than their mean, and/or the frequency of zero counts greater than expected for the Poisson distribution. This phenomenon is observable for both full- and partial-body exposure, but more pronounced for the latter. In this work, different methodologies for analyzing cytogenetic chromosomal aberrations datasets are compared, with special focus on zero-inflated Poisson and zero-inflated negative binomial models. A score test for testing for zero inflation in Poisson regression models under the identity link is also developed.

Citation

Oliveira, M., Einbeck, J., Higueras, M., Ainsbury, E., Puig, P., & Rothkamm, K. (2016). Zero-inflated regression models for radiation-induced chromosome aberration data: A comparative study. Biometrical Journal, 58(2), 259-279. https://doi.org/10.1002/bimj.201400233

Journal Article Type Article
Acceptance Date Aug 3, 2015
Online Publication Date Oct 7, 2015
Publication Date Mar 1, 2016
Deposit Date Jan 8, 2016
Publicly Available Date Mar 28, 2024
Journal Biometrical Journal
Print ISSN 0323-3847
Electronic ISSN 1521-4036
Publisher Wiley-VCH Verlag
Peer Reviewed Peer Reviewed
Volume 58
Issue 2
Pages 259-279
DOI https://doi.org/10.1002/bimj.201400233
Keywords Biological dosimetry, Chromosome aberrations, Count data, Overdispersion, Score tests, Zero inflation.
Related Public URLs http://www.ncbi.nlm.nih.gov/pubmed/26461836

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Accepted Journal Article (292 Kb)
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Copyright Statement
This is the accepted version of the following article: Oliveira, María, Einbeck, Jochen, Higueras, Manuel, Ainsbury, Elizabeth, Puig, Pedro and Rothkamm, Kai (2016) Zero-inflated regression models for radiation-induced chromosome aberration data: a comparative study. Biometrical journal, 58(2): 259-279, which has been published in final form at http://dx.doi.org/10.1002/bimj.201400233. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.





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