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Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers

Johnson, D.W.; Langford, C.R.; Didsbury, M.P.; Lipp, B.; Przyborski, S.A.; Cameron, N.R.

Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers Thumbnail


Authors

D.W. Johnson

C.R. Langford

M.P. Didsbury

B. Lipp

N.R. Cameron



Abstract

The emulsion templating process offers a route to highly porous polymers with well-defined morphologies. This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materials have nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 μm. Initial biocompatibility assessments with fibroblast cells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml−1.

Citation

Johnson, D., Langford, C., Didsbury, M., Lipp, B., Przyborski, S., & Cameron, N. (2015). Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers. Polymer Chemistry, 6(41), 7256-7263. https://doi.org/10.1039/c5py00721f

Journal Article Type Article
Acceptance Date Jun 8, 2015
Online Publication Date Jun 9, 2015
Publication Date Nov 7, 2015
Deposit Date Jan 4, 2016
Publicly Available Date Mar 29, 2024
Journal Polymer Chemistry
Print ISSN 1759-9954
Electronic ISSN 1759-9962
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 6
Issue 41
Pages 7256-7263
DOI https://doi.org/10.1039/c5py00721f

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