Skip to main content

Research Repository

Advanced Search

Base-Specific Ionization of Deprotonated Nucleotides by Resonance Enhanced Two-Photon Detachment

Chatterley, A.S.; Johns, A.S.; Stavros, V.G.; Verlet, J.R.R.

Base-Specific Ionization of Deprotonated Nucleotides by Resonance Enhanced Two-Photon Detachment Thumbnail


Authors

A.S. Chatterley

A.S. Johns

V.G. Stavros



Abstract

The intrinsic ionization energy of a base in DNA plays a critical role in determining the energies at which damage mechanisms may emerge. Here, a two-photon resonance-enhanced ionization scheme is presented that utilizes the 1ππ* transition, localized on the DNA base, to elucidate the base-specific ionization in a deprotonated nucleotide. In contrast to previous reports, the scheme is insensitive to competing ionization channels arising from the sugar–phosphate backbone. Using this approach, we demonstrate that for all bases except guanine, the lowest electron detachment energy corresponds to detachment from the sugar–phosphate backbone and allows us to determine the lowest adiabatic ionization energy for the other three bases for the first time in an isolated nucleotide.

Citation

Chatterley, A., Johns, A., Stavros, V., & Verlet, J. (2013). Base-Specific Ionization of Deprotonated Nucleotides by Resonance Enhanced Two-Photon Detachment. The Journal of Physical Chemistry A, 117(25), 5299-5305. https://doi.org/10.1021/jp4041315

Journal Article Type Article
Publication Date Jun 27, 2013
Deposit Date Jan 27, 2016
Publicly Available Date Mar 29, 2024
Journal The Journal of Physical Chemistry A
Print ISSN 1089-5639
Electronic ISSN 1520-5215
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 117
Issue 25
Pages 5299-5305
DOI https://doi.org/10.1021/jp4041315

Files

Accepted Journal Article (580 Kb)
PDF

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Physical Chemistry A, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jp4041315.




You might also like



Downloadable Citations