Jason H. Gill
Oncology Activity
Gill, Jason H.; Shnyder, Steven D.
Authors
Steven D. Shnyder
Contributors
Franz J. Hock
Editor
Abstract
The development of therapeutics to treat cancer is conceptually more difficult than for nonlife-threatening diseases for several reasons, including its complex pathophysiological nature, the molecular individuality of each tumor, and the robustness and predictability of preclinical models toward determining efficacy and safety. A major limitation to development of a “blockbuster” therapeutic strategy is the infinite combination of cellular and molecular perturbations and associated heterogeneity of causative genetic factors driving disease progression. Although challenging, the diversity of drug targets, coupled with the lethality of the disease, has encouraged studies of a vast array of approaches and opportunities for disease treatment over the years.
Citation
Gill, J. H., & Shnyder, S. D. (2016). Oncology Activity. In F. J. Hock (Ed.), Drug discovery and evaluation : pharmacological assays (4157-4200). (4th ed.). Springer Verlag. https://doi.org/10.1007/978-3-319-05392-9_113
Acceptance Date | Dec 21, 2015 |
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Publication Date | Jan 1, 2016 |
Deposit Date | Dec 21, 2015 |
Publicly Available Date | Mar 28, 2024 |
Publisher | Springer Verlag |
Pages | 4157-4200 |
Series Title | Springer reference |
Edition | 4th ed. |
Book Title | Drug discovery and evaluation : pharmacological assays. |
ISBN | 9783319053912 |
DOI | https://doi.org/10.1007/978-3-319-05392-9_113 |
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