H.L. Bolt
A practical method for the synthesis of peptoids containing both lysine-type and arginine-type monomers
Bolt, H.L.; Cobb, S.L.
Abstract
Peptoids are a promising class of peptidomimetics that exhibit the key chemical and physical properties of peptides but without being hampered by susceptibility towards enzymatic degradation. Biologically active peptoids are often designed to be amphipathic in nature, consisting of hydrophobic monomers interspersed with either cationic lysine-type or arginine-type monomers. Access to amphipathic peptoids that contain both lysine-type and arginine-type monomers is highly desirable as it offers a route to further modulate the biological properties of this class of molecule. However, the lack of a suitable synthetic route to prepare mixed cationic peptoids has meant that their biological potential has remained almost largely unexplored. Herein, we present an efficient synthetic route that can be used to access novel cationic peptoids containing both lysine-type and arginine-type monomers within the same sequence.
Citation
Bolt, H., & Cobb, S. (2016). A practical method for the synthesis of peptoids containing both lysine-type and arginine-type monomers. Organic and Biomolecular Chemistry, 14(4), 1211-1215. https://doi.org/10.1039/c5ob02279g
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 8, 2015 |
Online Publication Date | Dec 8, 2015 |
Publication Date | Jan 28, 2016 |
Deposit Date | Oct 2, 2015 |
Publicly Available Date | Mar 28, 2024 |
Journal | Organic and Biomolecular Chemistry |
Print ISSN | 1477-0520 |
Electronic ISSN | 1477-0539 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Issue | 4 |
Pages | 1211-1215 |
DOI | https://doi.org/10.1039/c5ob02279g |
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Publisher Licence URL
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Copyright Statement
This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
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