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A practical method for the synthesis of peptoids containing both lysine-type and arginine-type monomers

Bolt, H.L.; Cobb, S.L.

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Authors

H.L. Bolt



Abstract

Peptoids are a promising class of peptidomimetics that exhibit the key chemical and physical properties of peptides but without being hampered by susceptibility towards enzymatic degradation. Biologically active peptoids are often designed to be amphipathic in nature, consisting of hydrophobic monomers interspersed with either cationic lysine-type or arginine-type monomers. Access to amphipathic peptoids that contain both lysine-type and arginine-type monomers is highly desirable as it offers a route to further modulate the biological properties of this class of molecule. However, the lack of a suitable synthetic route to prepare mixed cationic peptoids has meant that their biological potential has remained almost largely unexplored. Herein, we present an efficient synthetic route that can be used to access novel cationic peptoids containing both lysine-type and arginine-type monomers within the same sequence.

Citation

Bolt, H., & Cobb, S. (2016). A practical method for the synthesis of peptoids containing both lysine-type and arginine-type monomers. Organic and Biomolecular Chemistry, 14(4), 1211-1215. https://doi.org/10.1039/c5ob02279g

Journal Article Type Article
Acceptance Date Dec 8, 2015
Online Publication Date Dec 8, 2015
Publication Date Jan 28, 2016
Deposit Date Oct 2, 2015
Publicly Available Date Mar 28, 2024
Journal Organic and Biomolecular Chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 14
Issue 4
Pages 1211-1215
DOI https://doi.org/10.1039/c5ob02279g

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