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Stall force of polymerizing microtubules and filament bundles

Krawczyk, J.; Kierfeld, J.

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Authors

J. Krawczyk

J. Kierfeld



Abstract

We investigate stall force and polymerization kinetics of rigid protofilaments in a microtubule or interacting filaments in bundles under an external load force in the framework of a discrete growth model. We introduce the concecpt of polymerization cycles to describe the stochastic growth kinetics, which allows us to derive an exact expression for the stall force. We find that the stall force is independent of ensemble geometry and load distribution. Furthermore, the stall force is proportional to the number of filaments and increases linearly with the strength of lateral filament interactions. These results are corroborated by simulations, which also show a strong influence of ensemble geometry on growth kinetics below the stall force.

Citation

Krawczyk, J., & Kierfeld, J. (2011). Stall force of polymerizing microtubules and filament bundles. European Physical Society Letters, 93(2), Article 28006. https://doi.org/10.1209/0295-5075/93/28006

Journal Article Type Article
Acceptance Date Jan 5, 2011
Publication Date Feb 7, 2011
Deposit Date Dec 30, 2015
Publicly Available Date Mar 29, 2024
Journal Europhysics Letters
Print ISSN 0295-5075
Electronic ISSN 1286-4854
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 93
Issue 2
Article Number 28006
DOI https://doi.org/10.1209/0295-5075/93/28006
Related Public URLs http://arxiv.org/abs/1102.2013

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Copyright Statement
This is an author-created, un-copyedited version of an article published in Europhysics letters. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://dx.doi.org/10.1209/0295-5075/93/28006




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