Fluorination of pyrrole derivatives by Selectfluor™

Heeran, D.; Sandford, G.

doi:10.1016/j.tet.2016.03.067

Fluorination of pyrrole derivatives by Selectfluor™

Heeran, D.; Sandford, G.

Authors

D. Heeran

G. Sandford

Abstract

Fluorination of a range of pyrrole substrates bearing various electron donating and withdrawing substituents at the 1-, 2- and 3-positons using Selectfluor™ has been assessed in order to develop effective methodology for the synthesis of corresponding fluoropyrrole derivatives. The synthesis of some novel fluorinated pyrrole derivatives were achieved in reasonable quantities although many pyrrole substrates were oxidatively polymerised by the fluorinating reagent, reducing the scope of a selective fluorination approach for the preparation of fluoropyrrole products.

Citation

Heeran, D., & Sandford, G. (2016). Fluorination of pyrrole derivatives by Selectfluor™. Tetrahedron, 72(19), 2456-2463. https://doi.org/10.1016/j.tet.2016.03.067

Journal Article Type	Article
Acceptance Date	Mar 21, 2016
Online Publication Date	Mar 24, 2016
Publication Date	May 12, 2016
Deposit Date	Apr 11, 2016
Publicly Available Date	Mar 24, 2017
Journal	Tetrahedron
Print ISSN	0040-4020
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	72
Issue	19
Pages	2456-2463
DOI	https://doi.org/10.1016/j.tet.2016.03.067

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http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
© 2016 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/