Stabilisation of an amorphous form of ROY through a predicted co-former interaction

Corner, Philip A.; Harburn, J. Jonathan; Steed, Jonathan W.; McCabe, James F.; Berry, David J.

doi:10.1039/c6cc02949c

Stabilisation of an amorphous form of ROY through a predicted co-former interaction

Corner, Philip A.; Harburn, J. Jonathan; Steed, Jonathan W.; McCabe, James F.; Berry, David J.

Authors

Philip A. Corner

J. Jonathan Harburn

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

James F. McCabe

David J. Berry

Abstract

The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours.

Citation

Corner, P. A., Harburn, J. J., Steed, J. W., McCabe, J. F., & Berry, D. J. (2016). Stabilisation of an amorphous form of ROY through a predicted co-former interaction. Chemical Communications, 52(39), 6537-6540. https://doi.org/10.1039/c6cc02949c

Journal Article Type	Article
Acceptance Date	Apr 18, 2016
Online Publication Date	Apr 18, 2016
Publication Date	May 14, 2016
Deposit Date	Apr 18, 2016
Publicly Available Date	Apr 18, 2017
Journal	Chemical Communications
Print ISSN	1359-7345
Electronic ISSN	1364-548X
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	52
Issue	39
Pages	6537-6540
DOI	https://doi.org/10.1039/c6cc02949c