Ebaa M. El-Hossary
Synthesis and antibacterial activity of novel 2-(arylimino)thiazolidin-4-one and 2-(benzylidenehydrazono)-3-arylthiazolidin-4-one derivatives
El-Hossary, Ebaa M.; Nissan, Yassin M.; Edkins, Katharina; Bruhn, Heike
Authors
Yassin M. Nissan
Katharina Edkins
Heike Bruhn
Abstract
The ongoing spread of multidrug-resistant bacteria demands an intensive search for new antibacterial agents. In the present study, a series of new 1,3-thiazolidin-4-ones has been synthesized and investigated for its in vitro antibacterial activity. The most potent antibacterial compound 4c was found to be active, at low micromolar range, against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and the pneumonic plague causative agent Yersinia pestis with minimum inhibitory concentrations of 5 µM, 2.5 µM, 2.5 µM and 5 µM, respectively. Compound 4c showed the ability to kill E. faecalis JH212 strain with a minimum bactericidal concentration of 5 µM. Furthermore, compounds 9b and 10a inhibited the biofilm formation in S. epidermidis, where they showed 70% to 80% inhibition at a concentration of 40 µM.
Citation
El-Hossary, E. M., Nissan, Y. M., Edkins, K., & Bruhn, H. (2016). Synthesis and antibacterial activity of novel 2-(arylimino)thiazolidin-4-one and 2-(benzylidenehydrazono)-3-arylthiazolidin-4-one derivatives. Journal of Applied Pharmaceutical Science, 6(05), 007-017. https://doi.org/10.7324/japs.2016.60502
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Apr 8, 2016 |
| Online Publication Date | May 28, 2016 |
| Publication Date | May 28, 2016 |
| Deposit Date | Jun 9, 2016 |
| Publicly Available Date | Jun 10, 2016 |
| Journal | Journal of Applied Pharmaceutical Science |
| Publisher | Journal of Applied Pharmaceutical Science |
| Peer Reviewed | Peer Reviewed |
| Volume | 6 |
| Issue | 05 |
| Pages | 007-017 |
| DOI | https://doi.org/10.7324/japs.2016.60502 |
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Copyright Statement
© 2016 Ebaa M. El-Hossary et al. This is an open access article distributed under the terms of the Creative Commons Attribution License-NonCommercial-ShareAlikeUnported License (http://creativecommons.org/licenses/by-nc-sa/3.0/).
Published Journal Article
(560 Kb)
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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-sa/3.0
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