L. Zhou
Drug Allergies Documented in Electronic Health Records of a Large Healthcare System
Zhou, L.; Dhopeshwarkar, N.; Blumenthal, K.G.; Goss, F.; Topaz, M.; Slight, S.P.; Bates, D.W.
Authors
N. Dhopeshwarkar
K.G. Blumenthal
F. Goss
M. Topaz
S.P. Slight
D.W. Bates
Abstract
Background The prevalence of drug allergies documented in electronic health records (EHRs) of large patient populations is understudied. Objective We aimed to describe the prevalence of common drug allergies and patient characteristics documented in EHRs of a large healthcare network over the last two decades. Methods Drug allergy data were obtained from EHRs of patients who visited two large tertiary care hospitals in Boston from 1990 to 2013. The prevalence of each drug and drug class was calculated and compared by sex and race/ethnicity. The number of allergies per patient was calculated and the frequency of patients having 1, 2, 3…, or 10+ drug allergies was reported. We also conducted a trend analysis by comparing the proportion of each allergy to the total number of drug allergies over time. Results Among 1 766 328 patients, 35.5% of patients had at least one reported drug allergy with an average of 1.95 drug allergies per patient. The most commonly reported drug allergies in this population were to penicillins (12.8%), sulfonamide antibiotics (7.4%), opiates (6.8%), and nonsteroidal anti-inflammatory drugs (NSAIDs) (3.5%). The relative proportion of allergies to angiotensin-converting enzyme (ACE) inhibitors and HMG CoA reductase inhibitors (statins) have more than doubled since early 2000s. Drug allergies were most prevalent among females and white patients except for NSAIDs, ACE inhibitors, and thiazide diuretics, which were more prevalent in black patients. Conclusion Females and white patients may be more likely to experience a reaction from common medications. An increase in reported allergies to ACE inhibitors and statins is noteworthy.
Citation
Zhou, L., Dhopeshwarkar, N., Blumenthal, K., Goss, F., Topaz, M., Slight, S., & Bates, D. (2016). Drug Allergies Documented in Electronic Health Records of a Large Healthcare System. Allergy, 71(9), 1305-1313. https://doi.org/10.1111/all.12881
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 14, 2016 |
Online Publication Date | Apr 6, 2016 |
Publication Date | Sep 1, 2016 |
Deposit Date | Jun 29, 2016 |
Publicly Available Date | Apr 6, 2017 |
Journal | Allergy |
Print ISSN | 0105-4538 |
Electronic ISSN | 1398-9995 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 71 |
Issue | 9 |
Pages | 1305-1313 |
DOI | https://doi.org/10.1111/all.12881 |
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Copyright Statement
This is the accepted version of the following article: Zhou L, Dhopeshwarkar N, Blumenthal KG, Goss F, Topaz M, Slight SP, Bates DW. Drug allergies documented in electronic health records of a large healthcare system. Allergy, 71(9): 1305-1313, which has been published in final form at http://dx.doi.org/10.1111/all.12881. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
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