Cavity-Containing Supramolecular Gels as a Crystallization Tool for Hydrophobic Pharmaceuticals

Kaufmann, Lena; Kennedy, Stuart R.; Jones, Christopher D.; Steed, Jonathan W.

doi:10.1039/c6cc04037c

Cavity-Containing Supramolecular Gels as a Crystallization Tool for Hydrophobic Pharmaceuticals

Kaufmann, Lena; Kennedy, Stuart R.; Jones, Christopher D.; Steed, Jonathan W.

Authors

Lena Kaufmann

Stuart R. Kennedy

Christopher D. Jones

Professor Jonathan Steed jon.steed@durham.ac.uk
Professor

Abstract

We present two approaches to low-molecular-weight supramolecular gels bearing hydrophobic cavities based on calixarene-containing building blocks. Gels are formed by a calixarene based tetrahydrazide gelator or a co-gel of a calixarene diammonium salt and a bis-crown ether. The calixarene hydrophobic cavity enables the complexation of hydrophobic drug molecules in a generic fashion thus providing an anchor site on the surface of the gel fibre to inititate drug crystal nucleation and growth. This technique potentially represents a route to growth of hard-to-nucleate polymorphic modifications. The co-gel comprising two components holding together by non-covalent ammonium-crown ether interaction can be easily switched back to the sol state by adding competitive binding cations.

Citation

Kaufmann, L., Kennedy, S. R., Jones, C. D., & Steed, J. W. (2016). Cavity-Containing Supramolecular Gels as a Crystallization Tool for Hydrophobic Pharmaceuticals. Chemical Communications, 52(66), 10113-10116. https://doi.org/10.1039/c6cc04037c

Journal Article Type	Article
Acceptance Date	Jun 29, 2016
Online Publication Date	Jun 29, 2016
Publication Date	Aug 25, 2016
Deposit Date	Jun 30, 2016
Publicly Available Date	Jun 30, 2016
Journal	Chemical Communications
Print ISSN	1359-7345
Electronic ISSN	1364-548X
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	52
Issue	66
Pages	10113-10116
DOI	https://doi.org/10.1039/c6cc04037c