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Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies

Lethbridge, N.L.; Chazot, P.L.

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Authors

N.L. Lethbridge



Abstract

Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 receptors (H3R) in a series of major cortical and basal ganglia structures in human DLB and Alzheimer’s (AD) post-mortem cases using the highly selective radioligand, [3H] GSK189254. In the main, the levels of H3 receptor were largely preserved in DLB cases when compared with aged-matched controls. However, we provide new evidence showing variable levels in the globus pallidus, and, moreover, raised levels of Pallidum H3 correlated with positive psychotic symptoms, in particular delusions and visual hallucinations, but not symptoms associated with depression. Furthermore, no correlation was detected for H3 receptor levels to MMSE or IUPRS symptom severity. This study suggests that H3R antagonists have scope for treating the psychotic symptomologies in DLB and other human brain disorders.

Citation

Lethbridge, N., & Chazot, P. (2016). Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies. Pharmacological Research, 113(Part A), 245-256. https://doi.org/10.1016/j.phrs.2016.08.034

Journal Article Type Article
Acceptance Date Aug 31, 2016
Online Publication Date Aug 31, 2016
Publication Date Nov 1, 2016
Deposit Date Sep 7, 2016
Publicly Available Date Sep 8, 2016
Journal Pharmacological Research
Print ISSN 1043-6618
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 113
Issue Part A
Pages 245-256
DOI https://doi.org/10.1016/j.phrs.2016.08.034

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