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The influence of genotype information on psychiatrists’ treatment recommendations: more experienced clinicians know better what to ignore

McMichel, A.; Boeri, M.; Rolison, J.; Kane, J.; O’Neill, F.; Kee, F.; Scarpa, R.

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Authors

A. McMichel

M. Boeri

J. Rolison

J. Kane

F. O’Neill

F. Kee



Abstract

Background This study applies attribute nonattendance to medical decision making. We aimed to demonstrate how this type of analysis can be used in medical decision making to assess whether psychiatrists were influenced in their treatment recommendations by information on the genotype of a patient, despite knowing the patient’s response to treatment as measured by the Positive and Negative Syndrome Scale. A patient’s genetic information may be used to predict their response to therapy; such information, however, becomes redundant, and should not influence decisions, once a clinician knows the patient’s actual response to treatment. Methods Sixty-seven psychiatrists were presented with patients’ pre- or post-treatment scores on the Positive and Negative Syndrome Scale for two hypothetical treatments for schizophrenia. Psychiatrists were also informed whether the patient possessed a genotype linked to hyper-responsiveness to one of the treatments, and were asked to recommend one of these two treatments. Attribute nonattendance assessed whether the information on genotype influenced psychiatrists’ treatment recommendations. Results Years of experience predicted whether psychiatrists were influenced by the genetic information. Psychiatrists with 1 year or less of experience had a 46% probability of considering genetic information, whereas psychiatrists with at least 15 years of experience had a lower probability (7%). Conclusions Psychiatrists and other clinicians should be cautious about allowing a patient’s genetic information to carry unnecessary weight in their clinical decision making.

Citation

McMichel, A., Boeri, M., Rolison, J., Kane, J., O’Neill, F., Kee, F., & Scarpa, R. (2017). The influence of genotype information on psychiatrists’ treatment recommendations: more experienced clinicians know better what to ignore. Value in Health, 20(1), 126-131. https://doi.org/10.1016/j.jval.2016.09.2395

Journal Article Type Article
Acceptance Date Sep 5, 2016
Online Publication Date Nov 4, 2016
Publication Date Jan 1, 2017
Deposit Date Sep 15, 2016
Publicly Available Date Mar 29, 2024
Journal Value in Health
Print ISSN 1098-3015
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 20
Issue 1
Pages 126-131
DOI https://doi.org/10.1016/j.jval.2016.09.2395
Public URL https://durham-repository.worktribe.com/output/1374948

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