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Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors

Cross, J.M.; Blower, T.R.; Gallagher, N.; Gill, J.H.; Rockley, K.L.; Walton, J.W.

Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors Thumbnail


Authors

J.M. Cross

N. Gallagher

J.H. Gill

K.L. Rockley



Abstract

The first examples of RuII and RhIII piano-stool complex histone deacetylase (HDAC) inhibitors are presented. The novel complexes have antiproliferative activity against H460 non-small-cell lung carcinoma cells that is comparable to the clinically used HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). Strong evidence for HDAC inhibition as a primary mechanism of action is provided. The complexes reported here represent an important step towards the design of highly active and selective HDAC inhibitors.

Citation

Cross, J., Blower, T., Gallagher, N., Gill, J., Rockley, K., & Walton, J. (2016). Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors. ChemPlusChem, 81(12), 1276-1280. https://doi.org/10.1002/cplu.201600413

Journal Article Type Article
Acceptance Date Sep 21, 2016
Online Publication Date Oct 12, 2016
Publication Date Dec 1, 2016
Deposit Date Sep 22, 2016
Publicly Available Date Mar 28, 2024
Journal ChemPlusChem
Electronic ISSN 2192-6506
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 81
Issue 12
Pages 1276-1280
DOI https://doi.org/10.1002/cplu.201600413

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Advance online version © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.






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