The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient

Forssell-Aronsson, E.; Quinlan, R.A.

doi:10.1093/rpd/ncw328

The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient

Forssell-Aronsson, E.; Quinlan, R.A.

Authors

E. Forssell-Aronsson

Professor Roy Quinlan r.a.quinlan@durham.ac.uk
Emeritus Professor

Abstract

Daily rhythmic changes are found in cellular events in cell cycle, DNA repair, apoptosis and angiogenesis in both normal and tumour tissue, as well as in enzymatic activity and drug metabolism. In this paper, we hypothesize that circadian rhythms need to be considered in radiation protection and optimization in personalized medicine, especially for paediatric care. The sensitivity of the eye lens to ionizing radiation makes the case for limiting damage to the lens epithelium by planning medical radio-imaging procedures for the afternoon, rather than the morning. Equally, the tumour and normal tissue response to radiotherapy is also subject to diurnal variation enabling optimization of time of treatment.

Citation

Forssell-Aronsson, E., & Quinlan, R. (2017). The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient. Radiation Protection Dosimetry, 173(1-3), 16-20. https://doi.org/10.1093/rpd/ncw328

Journal Article Type	Article
Acceptance Date	Oct 28, 2016
Online Publication Date	Nov 15, 2016
Publication Date	Apr 1, 2017
Deposit Date	Nov 14, 2016
Publicly Available Date	Nov 15, 2017
Journal	Radiation Protection Dosimetry
Print ISSN	0144-8420
Electronic ISSN	1742-3406
Publisher	Oxford University Press
Peer Reviewed	Peer Reviewed
Volume	173
Issue	1-3
Pages	16-20
DOI	https://doi.org/10.1093/rpd/ncw328

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Copyright Statement
This is a pre-copyedited, author-produced version of an article accepted for publication in Radiation Protection Dosimetry following peer review. The version of record Forssell-Aronsson, E. & Quinlan, R.A. (2017). The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient. Radiation Protection Dosimetry, 173 (1-3): 16-20 is available online at: https://doi.org/10.1093/rpd/ncw328.