Peptoid efficacy against polymicrobial biofilms determined using propidium monoazide-modified quantitative PCR

Luoa, Y.; Bolt, H.L.; Eggimann, G.A.; McAuley, D.F.; McMullan, R.; Curran, T.; Zhoud, M.; Jahoda, C.A.B.; Cobb, S.L.; Lundy, F.T.

doi:10.1002/cbic.201600381

Peptoid efficacy against polymicrobial biofilms determined using propidium monoazide-modified quantitative PCR

Luoa, Y.; Bolt, H.L.; Eggimann, G.A.; McAuley, D.F.; McMullan, R.; Curran, T.; Zhoud, M.; Jahoda, C.A.B.; Cobb, S.L.; Lundy, F.T.

Authors

Y. Luoa

H.L. Bolt

G.A. Eggimann

D.F. McAuley

R. McMullan

T. Curran

M. Zhoud

C.A.B. Jahoda

Professor Steven Cobb s.l.cobb@durham.ac.uk
Professor

F.T. Lundy

Abstract

Biofilms containing C. albicans are responsible for a wide variety of clinical infections. The protective effects of the biofilm matrix, the low metabolic activity of microorganisms within a biofilm and their high mutation rate, significantly enhance the resistance of biofilms to conventional antimicrobial treatments. Peptoids are peptide-mimics that share many features of host defence antimicrobial peptides, but have increased resistance to proteinases and therefore better stability in vivo. The activity of a library of peptoids was tested against both monospecies and polymicrobial bacterial/fungal biofilms. Selected peptoids showed significant bactericidal and fungicidal activity against the polymicrobial biofilms. This coupled with low cytotoxicity, suggests that peptoids could offer a new option for the treatment of clinically relevant polymicrobial infections in the future.

Citation

Luoa, Y., Bolt, H., Eggimann, G., McAuley, D., McMullan, R., Curran, T., …Lundy, F. (2017). Peptoid efficacy against polymicrobial biofilms determined using propidium monoazide-modified quantitative PCR. ChemBioChem, 18(1), 111-118. https://doi.org/10.1002/cbic.201600381

Journal Article Type	Article
Acceptance Date	Oct 28, 2016
Online Publication Date	Nov 30, 2016
Publication Date	Jan 3, 2017
Deposit Date	Mar 3, 2016
Publicly Available Date	Nov 15, 2016
Journal	ChemBioChem
Print ISSN	1439-4227
Electronic ISSN	1439-7633
Publisher	Wiley-VCH Verlag
Peer Reviewed	Peer Reviewed
Volume	18
Issue	1
Pages	111-118
DOI	https://doi.org/10.1002/cbic.201600381

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© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.