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The RooPfs study to assess whether improved housing provides additional protection against clinical malaria over current best practice in The Gambia: study protocol for a randomized controlled study and ancillary studies

Pinder, M.; Conteh, L.; Jeffries, D.; Jones, C.; Knudsen, J.; Kandeh, B.; Jawara, M.; Sicuri, E.; D'Alessandro, U.; Lindsay, S.W.

The RooPfs study to assess whether improved housing provides additional protection against clinical malaria over current best practice in The Gambia: study protocol for a randomized controlled study and ancillary studies Thumbnail


Authors

M. Pinder

L. Conteh

D. Jeffries

C. Jones

J. Knudsen

B. Kandeh

M. Jawara

E. Sicuri

U. D'Alessandro



Abstract

Background In malaria-endemic areas, residents of modern houses have less malaria than those living in traditional houses. This study will determine if modern housing provides incremental protection against clinical malaria over the current best practice of long-lasting insecticidal nets (LLINs) and prompt treatment in The Gambia, determine the incremental cost-effectiveness of the interventions, and analyze the housing market in The Gambia. Methods/design A two-armed, household, cluster-randomized, controlled study will be conducted to assess whether improved housing and LLINs combine to provide better protection against clinical malaria in children than LLINs alone in The Gambia. The unit of randomization will be the household, defined as a house and its occupants. A total of 800 households will be enrolled and will receive LLINs, and 400 will receive improved housing before clinical follow-up. One child aged 6 months to 13 years will be enrolled from each household and followed for clinical malaria using active case detection to estimate malaria incidence for two malaria transmission seasons. Episodes of clinical malaria will be the primary endpoint. Study children will be surveyed at the end of each transmission season to estimate the prevalence of Plasmodium falciparum infection, parasite density, and the prevalence of anemia. Exposure to malaria parasites will be assessed using light traps, followed by detection of Anopheles gambiae species and sporozoite infection. Ancillary economic and social science studies will undertake a cost-effectiveness analysis and use qualitative and participatory methods to explore the acceptability of the housing modifications and to design strategies for scaling-up housing interventions. Discussion The study is the first of its kind to measure the efficacy of housing on reducing clinical malaria, assess the incremental cost-effectiveness of improved housing, and identify mechanisms for scaling up housing interventions. Trial findings will help inform policy makers on improved housing for malaria control in sub-Saharan Africa. Trial registration ISRCTN Registry, ISRCTN02622179. Registered on 23 September 2014.

Citation

Pinder, M., Conteh, L., Jeffries, D., Jones, C., Knudsen, J., Kandeh, B., …Lindsay, S. (2016). The RooPfs study to assess whether improved housing provides additional protection against clinical malaria over current best practice in The Gambia: study protocol for a randomized controlled study and ancillary studies. Trials, 17(1), Article 275. https://doi.org/10.1186/s13063-016-1400-7

Journal Article Type Article
Acceptance Date May 3, 2016
Online Publication Date Jun 3, 2016
Publication Date Jun 3, 2016
Deposit Date Dec 9, 2016
Publicly Available Date Mar 28, 2024
Journal Trials
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 17
Issue 1
Article Number 275
DOI https://doi.org/10.1186/s13063-016-1400-7

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.





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