How environment geometry affects grid cell symmetry and what we can learn from it

Krupic, J.; Bauza, M.; Burton, S.; Lever, C.; O'Keefe, J.

doi:10.1098/rstb.2013.0188

How environment geometry affects grid cell symmetry and what we can learn from it

Krupic, J.; Bauza, M.; Burton, S.; Lever, C.; O'Keefe, J.

Authors

J. Krupic

M. Bauza

S. Burton

Professor Colin Lever colin.lever@durham.ac.uk
Professor

J. O'Keefe

Abstract

The mammalian hippocampal formation provides neuronal representations of environmental location but the underlying mechanisms are unclear. The majority of cells in medial entorhinal cortex and parasubiculum show spatially periodic firing patterns. Grid cells exhibit hexagonal symmetry and form an important subset of this more general class. Occasional changes between hexagonal and non-hexagonal firing patterns imply a common underlying mechanism. Importantly, the symmetrical properties are strongly affected by the geometry of the environment. Here, we introduce a field–boundary interaction model where we demonstrate that the grid cell pattern can be formed from competing place-like and boundary inputs. We show that the modelling results can accurately capture our current experimental observations.

Citation

Krupic, J., Bauza, M., Burton, S., Lever, C., & O'Keefe, J. (2014). How environment geometry affects grid cell symmetry and what we can learn from it. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1635), Article 20130188. https://doi.org/10.1098/rstb.2013.0188

Journal Article Type	Article
Acceptance Date	Dec 20, 2013
Online Publication Date	Dec 23, 2013
Publication Date	Feb 5, 2014
Deposit Date	Jan 18, 2017
Publicly Available Date	Jan 19, 2017
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Print ISSN	0962-8436
Electronic ISSN	1471-2970
Publisher	The Royal Society
Peer Reviewed	Peer Reviewed
Volume	369
Issue	1635
Article Number	20130188
DOI	https://doi.org/10.1098/rstb.2013.0188

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Copyright Statement
© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.