Exploring the links between peptoid antibacterial activity and toxicity

Bolt, Hannah L.; Eggimann, Gabriela A.; Jahoda, Colin A.B.; Zuckermann, Ronald N.; Sharples, Gary J.; Cobb, Steven L.

doi:10.1039/c6md00648e

Exploring the links between peptoid antibacterial activity and toxicity

Bolt, Hannah L.; Eggimann, Gabriela A.; Jahoda, Colin A.B.; Zuckermann, Ronald N.; Sharples, Gary J.; Cobb, Steven L.

Authors

Hannah L. Bolt

Gabriela A. Eggimann

Colin A.B. Jahoda

Ronald N. Zuckermann

Dr Gary Sharples gary.sharples@durham.ac.uk
Associate Professor

Professor Steven Cobb s.l.cobb@durham.ac.uk
Professor

Abstract

Peptoids are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicty data is somewhat limited and as such rationally designing effective antimicrobial peptoids can be challenging. Herein, we present the toxicity profiling of a series of linear peptoids against mammalian cell lines (HaCaT and HepG2). The cytotoxicity of the peptoid library has then been correlated with their antibacterial properties against Gram-positive and Gram-negative bacteria and also to the hydrophobicity of the peptoid sequences. The work presented provides valuable data to aid in the future rational design of antimicrobial peptoids.

Citation

Bolt, H. L., Eggimann, G. A., Jahoda, C. A., Zuckermann, R. N., Sharples, G. J., & Cobb, S. L. (2017). Exploring the links between peptoid antibacterial activity and toxicity. MedChemComm, 8(5), 886-896. https://doi.org/10.1039/c6md00648e

Journal Article Type	Article
Acceptance Date	Jan 22, 2017
Online Publication Date	Feb 1, 2017
Publication Date	May 1, 2017
Deposit Date	Jan 30, 2017
Publicly Available Date	Feb 9, 2017
Journal	MedChemComm.
Print ISSN	2040-2503
Electronic ISSN	2040-2511
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	8
Issue	5
Pages	886-896
DOI	https://doi.org/10.1039/c6md00648e