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Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex

Neil, E.R.; Parker, D.

Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex Thumbnail


Authors

E.R. Neil



Abstract

A europium complex bearing a phenylboronic acid group has been created that binds reversibly in methanol to sialic acid and lactic acid, as signalled by changes in the Eu total emission spectrum and the induction of strong circularly polarised luminescence. An analogue lacking the boronate moiety displays no spectral response towards sialic acid. The CPL signature is distinctive for sialic acid, and differs from that observed with methyl sialate and N-acetyl glucosamine. A hypothetical binding model is promulgated, where binding of the amide carbonyl to the Eu centre occurs at the same time as the terminal diol group of the glycerol moiety chelates to the boron atom.

Citation

Neil, E., & Parker, D. (2017). Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex. RSC Advances, 7(8), 4531-4540. https://doi.org/10.1039/c6ra26662b

Journal Article Type Article
Acceptance Date Dec 14, 2016
Online Publication Date Jan 16, 2017
Publication Date Jan 16, 2017
Deposit Date Mar 2, 2017
Publicly Available Date Mar 29, 2024
Journal RSC Advances
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 7
Issue 8
Pages 4531-4540
DOI https://doi.org/10.1039/c6ra26662b

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