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Induced europium CPL for the selective signalling of phosphorylated amino-acids and O-phosphorylated hexapeptides

Neil, E.R.; Pal, R.; Fox, M.A.; Parker, D.

Induced europium CPL for the selective signalling of phosphorylated amino-acids and O-phosphorylated hexapeptides Thumbnail


Authors

E.R. Neil



Abstract

Two bright, europium(III) complexes based on an achiral heptadentate triazacyclononane ligand bearing two strongly absorbing chromophores have been evaluated for the selective emission and CPL signalling of various chiral O-phosphono-anions. Binding of O-phosphono-Ser and Thr gives rise to a strong induced CPL signature and a favoured Δ complex configuration is adopted. A similarly large induced CPL signal arises when [Eu·L1]2+ binds to lysophosphatidic acid (LPA), where the strong binding (log K 5.25 (295 K)) in methanol allowed its detection over the range 5 to 40 μM. Strong and chemoselective binding to the phosphorylated amino-acid residues was also observed with a set of four structurally related hexapeptides: in one case, the sign of the gem value in the ΔJ = 1 transition allowed differentiation between the binding to O-P-Ser and O-P-Tyr residues.

Citation

Neil, E., Pal, R., Fox, M., & Parker, D. (2016). Induced europium CPL for the selective signalling of phosphorylated amino-acids and O-phosphorylated hexapeptides. Dalton Transactions, 45(20), 8355-8366. https://doi.org/10.1039/c6dt01212d

Journal Article Type Article
Acceptance Date Apr 19, 2016
Online Publication Date Apr 20, 2016
Publication Date May 28, 2016
Deposit Date Mar 2, 2017
Publicly Available Date Mar 3, 2017
Journal Dalton Transactions
Print ISSN 1477-9226
Electronic ISSN 1477-9234
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 45
Issue 20
Pages 8355-8366
DOI https://doi.org/10.1039/c6dt01212d

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