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Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and Their Small-Molecule Model Compounds

Perrin, Andrea; Goodwin, Melissa J.; Musa, Osama M.; Berry, David J.; Corner, Philip; Edkins, Katharina; Yufit, Dmitry S.; Steed, Jonathan W.

Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and Their Small-Molecule Model Compounds Thumbnail


Authors

Andrea Perrin

Melissa J. Goodwin

Osama M. Musa

David J. Berry

Philip Corner

Katharina Edkins

Dmitry S. Yufit



Abstract

The solution hydration behavior of a series of lactam-based kinetic clathrate hydrate inhibitors (KHIs) has been studied in order to determine mechanistic insight into their KHI performance. IR and 1H NMR spectroscopic titration data were compared across a series of mono- and bis(lactam) model compounds, and solid-phase hydration behavior was examined by dynamic vapor sorption. The structures of several of the model compounds have been investigated by X-ray crystallography. The work reveals insight into the very low crystallinity and high hygroscopicity of these materials which is linked to their performance as KHIs. Analysis of water binding in sour gas systems, containing H2S and CO2, reveals no effect on the water affinity of the lactams, suggesting that sour gas components do not inhibit KHI performance, but rather promote clathrate hydrate formation.

Citation

Perrin, A., Goodwin, M. J., Musa, O. M., Berry, D. J., Corner, P., Edkins, K., …Steed, J. W. (2017). Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and Their Small-Molecule Model Compounds. Crystal Growth and Design, 17(6), 3236-3249. https://doi.org/10.1021/acs.cgd.7b00221

Journal Article Type Article
Acceptance Date Apr 21, 2017
Online Publication Date Apr 21, 2017
Publication Date Jun 7, 2017
Deposit Date Apr 27, 2017
Publicly Available Date Mar 29, 2024
Journal Crystal Growth and Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 17
Issue 6
Pages 3236-3249
DOI https://doi.org/10.1021/acs.cgd.7b00221

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b00221.





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